Britskí lekári vedú prvé experimenty s embryonálnymi kmeňovými bunkami v Európe | Medicínske právo
              

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Britskí lekári vedú prvé experimenty s embryonálnymi kmeňovými bunkami v Európe


 | 27.9.2011 | komentárov: 301

Lekári v Moorfields Eye Hospital v Londýne dostali zelenú na realizáciu prvej klinickej štúdie s použitím ľudských embryonálnych kmeňových buniek v Európe. Budú vstrekovať sietnicové bunky do očí 12 pacientov s nevyliečiteľnou chorobou, Stargardtovou škvrnitou dystrofiou, ktorá spôsobuje postupnú stratu zraku.

Obrazok Ochorenie sa vyvíja už v detstve a postihuje asi jedného z 10 000 ľudí. Spôsobuje postupnú stratu centrálneho videnia s tým, že postihnutému ostáva iba periférne videnie. Experiment bude testovať bezpečnosť používania náhradných sietnicových buniek známych ako sietnicové bunky pigmentového epitelu vytvorených z ľudských embryonálnych kmeňových buniek.

Míľnik

Na experimente vedci spolupracujú s Americkou bio-technologickou spoločnosťou Advanced Cell Technology (ACT), ktorá práve začala s liečbou pacientov v Kalifornii. Gary Rabin, predseda predstavenstva a generálny riaditeľ ACT, opísal tento experiment ako „ďalší míľnik v oblasti regeneratívnej medicíny“. Kmeňové bunky sú našimi najlepšími bunkami. Bunky z ľudských embryí majú potenciál premeniť sa na jeden zo zhruba 200 typov tkanív.

Línia kmeňových buniek bola v USA vytvorená pred niekoľkými rokmi za pomoci darovaného embrya, ktoré tvorilo len zopár buniek a bolo menšie ako špendlíková hlavička. Zástancovia tvrdia, že táto liečba má potenciál liečiť nielen slepotu ale mnoho iných ochorení, od srdcových chorôb po rakovinu. Odporcovia zas nesúhlasia s postupom, ktorý začína  zničením ľudského embrya.

Ďalšia americká spoločnosť, GERON, používa embryonálne kmeňové bunky na liečbu pacientov s poranením miechy. Experimenty, vrátane ACT a GERON, aktuálne testujú, či sú uvedené postupy bezpečné. Ak áno, následne sa zvýši počet použitých kmeňových buniek s cieľom skontrolovať účinnosť zavádzaných postupov.
Profesor James Bainbridge z Moorfields Eye Hospital hovorí: „Je tu reálna možnosť, že ľudia s ochoreniami sietnice oka, ktoré končia oslepnutím, vrátane choroby Stargardt či vekom podmienenej degenerácie sietnice, môžu v budúcnosti využiť možnosť transplantácie buniek sietnice.“

Profesor Chris Mason, predseda regeneratívnej medicíny, moderného centra biologického inžinierstva Univerzity  v Londýne tvrdí: „Aj keď ide primárne o bezpečnostné štúdie, experimenty nepochybne prispejú k nárastu základných znalostí o bunkovej terapii, a tým pomôžu posunúť celý odbor.“
Začiatkom tohto roka, Národný inštitút pre výskum zdravia (National Institute of Health Research) udelil Moorfieldskej nemocnici  a UCL inštitútu oftalmológie 26 miliónov libier na práce zamerané na zavedenie vedeckých poznatkov do nových foriem liečby pre ľudí s ochoreniami zraku, pre ktoré im hrozí oslepnutie.

AUTOR: Fergus Walsh
ZDROJOVÝ TEXT: Walsh, F.: UK medics lead Europe's first embryonic stem cell trial, BBC NEWS, September 22, 2011
OBRÁZOK: healthheap.com
PREKLAD: Anton Kapráľ
EDITOVAL: Zuzana Zoláková



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